The Role of Ion Gates
 

The ion gates are protein channels that regulate ion flow into and out of the cell. There are three gates that are associated with the action potential: m, h, and n. The m and h gates control sodium flow, while the n gate controls potassium flow. In the resting phase of the action potential, the m gate is closed, while the h gate is open. Therefore, sodium is neither leaving or entering the cell. The n gate is also closed, so potassium can neither leave nor enter the cell. During depolarization, the m gate opens allowing sodium to diffuse down its gradient, while the n gate is still closed. During repolarization, the h gate closes, preventing sodium from coming into the cell. The n gate is open during this phase so potassium moves out. In the undershoot phase, the m gate closes, the h gate stays closed, and the n gate stays open. Finally, the h gate opens, the n gate closes and resting state is once again achieved. This is illustrated in the figure below.

where

(A) = Resting State

(B) = Depolarization phase

(C) = Repolarization phase

(D) = Undershoot

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